What it's used for
- ADHD (children and adolescents; off-label in adults)
Read about: ADHD, Tourette syndrome & tic disorders
How it works: Stimulates alpha-2A receptors in the prefrontal cortex, strengthening attention and impulse control.
Common side effects
- Sleepiness
- Low blood pressure
- Slow heart rate
- Tiredness
Tapering considerations
- Must be reduced gradually — stopping suddenly can cause rebound high blood pressure.
For prescribers & facilitators
- Taper by no more than 1 mg every 3–7 days; monitor BP and pulse.
Sources
- 01Attention deficit hyperactivity disorder: diagnosis and management (NG87)
NICE Guideline, 2018
- 02The Maudsley Deprescribing Guidelines
Horowitz & Taylor, Wiley-Blackwell, 2024