Common withdrawal effects
- Return of ADHD symptoms
- Tiredness and oversleeping
- Low mood or irritability
- Increased appetite
- Rebound blood pressure (guanfacine, if stopped suddenly)
Tapering principles
1
Plan a trial break
A supervised break, often at a lower-demand time, helps show whether medication is still helping.
2
Taper non-stimulants
Guanfacine must be reduced gradually (e.g. 1 mg every 3–7 days) to avoid rebound high blood pressure.
3
Agree what to watch for
Ask family, teachers or colleagues what changes they notice.
Before you begin
- Never stop guanfacine abruptly.
- Watch mood closely in the first weeks off stimulants.
Research & sources
- 01Attention deficit hyperactivity disorder: diagnosis and management (NG87)
NICE Guideline, 2018
- 02The Maudsley Deprescribing Guidelines
Horowitz & Taylor, Wiley-Blackwell, 2024