What it's used for
- Schizophrenia
- Bipolar mania
- Prevention of bipolar relapse
Read about: Bipolar disorder, Schizophrenia
How it works: Blocks dopamine D2, serotonin 5-HT2A and other receptors.
Common side effects
- Significant weight gain
- Sedation
- Metabolic changes
Tapering considerations
- Relapse risk is higher with rapid discontinuation.
- Reductions of ~5–10% of current dose monthly are described.
For prescribers & facilitators
- Agree relapse signature and crisis plan before tapering.
Sources
- 01A method for tapering antipsychotic treatment that may minimize the risk of relapse
Horowitz, Jauhar, Natesan, Murray & Taylor, Schizophrenia Bulletin, 2021
- 02The Maudsley Deprescribing Guidelines
Horowitz & Taylor, Wiley-Blackwell, 2024