TaperCareby FeelGround
Integrative mental health
← Gabapentin & pregabalin

Pregabalin

Also known as Lyrica · Gabapentinoid

Withdrawal risk: High

What it's used for

  • Generalised anxiety disorder
  • Nerve pain
  • Epilepsy
  • Fibromyalgia (some countries)

Read about: Generalised anxiety disorder

How it works: Binds the α2δ subunit of calcium channels, reducing excitatory neurotransmitter release.

Common side effects

  • Dizziness
  • Drowsiness
  • Weight gain
  • Blurred vision
  • Dependence

Tapering considerations

  • Manufacturer advises at least 1 week; many people need weeks to months.
  • Liquid allows small steps.
Why smaller steps near the end →

For prescribers & facilitators

  • Controlled drug (Schedule 3, UK) because of misuse risk.
  • Respiratory depression risk with opioids.

Sources

  1. 01
  2. 02
    The Maudsley Deprescribing Guidelines

    Horowitz & Taylor, Wiley-Blackwell, 2024